Microbial Fermentation Development: Scale-up and Manufacturing

Upcoming certificate programs: September 23-26, 2014, May 19-22, 2015.  November 3-6, 2015.

The successful implementation of microbial fermentation technology requires optimization of a number of variables. A clear understanding of all aspects of this technology assures that upstream scientists and technicians are capable and confident in their handling of these processes.

This technical short course employs extensive hand-on laboratory work. Participants will thaw seed vials and perform scale-up operations from a shake flask to a bench top fermenter, to a pilot scale fermenter. Participants will also learn the fundamentals of microbial growth, cell line development and media composition and selection.

Key Learning Objectives

  • Understand the principles of microbial growth and growth kinetics
  • Understand what the various media components are and their functionality
  • Understand protein expression and production
  • Identify the critical components of fermenters: how they work and are used
  • The setup, preparation, sterilization and inoculation of a fermenter
  • Understand how mixing studies are performed and why
  • Understand the critical attributes to consider during scale-up
  • Define the procedures employed to harvest the fermenter
  • Learn the above in a simulated GMP environment following SOPs

This class is limited to 24 students - reserve your seat early to avoid being waitlisted.

Program Logistics

TAKE ADVANTAGE OF CROSS-TRAINING OPPORTUNITIES WITH ADDITIONAL BIOMANUFACTURING PROGRAMS AT THE BETC

Explore our full schedule and plan your personal or group training calendar. Registrations now being accepted. Learn more now.  >

Benefits of this interactive training

  • Improve your knowledge of operating and troubleshooting bench top and pilot scale fermenters
  • Increase your understanding of how to optimize cell growth using process controls and media development
  • Increase your knowledge and understanding of how to anticipate process excursions before they occur
  • Reduce the time required to become a subject matter expert in your field
  • Become cross-trained in fermentation scale up and become more valuable to your employer

Who should attend?

  • Biomanufacturing associates and operators involved in upstream operations
  • Biomanufacturing associates and operators currently trained in cell culture operations who want to become proficient in microbial fermentation
  • Biomanufacturing associates and operators involved in downstream processing who want to become cross-trained in fermentation
  • Project and program managers for equipment and material vendors that serve the biotechnology industry
  • Quality assurance personnel responsible for the review of upstream process documentation
  • Technical writers responsible for generating batch records and recipes
  • Process development associates
  • Research scientists
  • Bioprocess engineers

Register