Downstream Principles and Techniques

UPCOMING CERTIFICATE PROGRAMS: OCTOBER 14-17, 2014.  June 23-26, 2015. NOVEMBER 17-21, 2015.

Improve your basic skills in separation and purification of bio-manufactured products. This hands-on training includes theoretical background information on cell harvest and clarification, TFF, and chromatography, including column packing. You will also develop a better understanding of the various protein characteristics and how they affect the purification process, how resins are selected, and how a purification process is developed.

Class size is limited to 24 – reserve your seat early!

Key Learning Objectives

  • Understand the principles of centrifugation and how cell harvesting and clarification is completed
  • Understand the principles and applications for depth filtration
  • Understand how protein characteristics facilitate the purification process
  • Become familiar with the different types of chromatographic processes and the principles behind each type 
  • Identify the components of a chromatography system and their functions
  • Perform column packing and peak evaluation
  • Identify the components of a TFF system and their functions
  • Understand how viruses are inactivated and removed
  • Understand how a purification process is developed

Program Logistics


Explore our full schedule and plan your personal or group training calendar. Registrations now being accepted. Learn more now.  >

Benefits of this interactive training

  • Increase your knowledge of the operation, maintenance and troubleshooting of centrifuges, filtration systems, TFF systems and Chromatography systems
  • Decrease the number of process excursions and deviations due to operator error
  • Reduce the time required to become a subject matter expert in your field
  • Become cross-trained in purification procedures to diversify your skill set

Who should attend?

  • Biomanufacturing associates and operators involved in downstream operations
  • Biomanufacturing associates and operators involved in upstream processing who want to become cross-trained in purification
  • Biomanufacturing facility maintenance, metrology and engineering personnel responsible for purification areas
  • Project and program managers in the biomanufacturing industry 
  • Sales and marketing personnel for equipment and material manufacturers that serve the biotechnology industry
  • Quality assurance personnel responsible for the review of downstream process documentation
  • Technical writers responsible for generating batch records and recipes
  • Process development associates
  • Research scientists
  • Bioprocess engineers